Table 3. Comparison of detection of EGFR mutation in the paired plasma and tissue samples (N=203).

Parameter	Plasma
	Mut	Wt	Total
Tissue
Mut	63	56	119
Wt	1	83	84
Total	64	139	203
Sensitivity†	52.9% (49.0–53.7%)
Specificity†	98.8% (93.3–99.9%)
PPV	98.4% (91.2–99.9%)
NPV	59.7% (56.4–60.4%)
Overall agreement†	71.9% (67.3–72.9%)

^†, percentage [95% confidence interval (CI)]; Mut, mutation; Wt, wild type; PPV, positive prediction value; NPV, negative prediction value.