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. 2019 May 1;14:3177–3188. doi: 10.2147/IJN.S188842

Figure 1.

Figure 1

(A) The chemical structure of sinomenine hydrochloride, phospholipid, and ascorbyl palmitate. (B) The ethosomal sizes were prepared by different stirring velocities and time on the basis of the stirring-injection method. (C) The ethosomal sizes were prepared by different injection velocities, ultrasound time, and probe ultrasound time based on ultrasound-injection method. (D) The capsulation efficiency with different edge activators (*P<0.05 vs E). (E) The deformability indexes under 0.3 and 0.5 MPa were measured by self-made equipment on the right. (*P< 0.05 vs E). (F) The cumulative permeation rates in vitro of control (sinomenine hydrochloride normal saline solution), E, and TE1, containing different concentrations of sodium deoxycholate, and AS-TE. (*P <0.05 vs control and TE1 containing 5.0 mg/mL of sodium deoxycholate). (G) The TEM images of E, TE1, and AS-TE.

Abbreviations: E, ethosome; TE, transethosomes (ethosome containing sodium deoxycholate (TE1), tween-80 (TE2) and oleic acid (TE3)); AS-TE, antioxidant surface transethosome.