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. 2019 May 1;14:3177–3188. doi: 10.2147/IJN.S188842

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© 2019 Song et al.

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The representative chromatograms of (A) plasma pharmacokinetic and (B) micro-dialysis sample. (C) The blood concentration-time profiles of healthy rabbits (control: sinomenine hydrochloride solution gel). (D) The diameters of knee joint and inflammation cytokines of rheumatoid arthritis model rabbits (*P < 0.05 vs control: healthy rabbits). (E) The synovial fluid concentration-time profiles of rheumatoid arthritis model rabbits (*P < 0.05 vs TE1).

Abbreviations: E, ethosome; TE1, transethosomes (ethosome containing sodium deoxycholate (TE1)); AS-TE, antioxidant surface transethosome.