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. 2019 May 2;10:43–63. doi: 10.2147/VMRR.S194427

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© 2019 Bright et al.

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Ingenuity® Pathway Analysis (IPA) predicted decreases in three and increases in four neutrophil functions. An interactive network was derived using IPA by screening 1,003 proteins in bronchoalveolar lavage fluid (BALF) of asthmatic vs control horses for their impact on neutrophil activity. Green shades indicate relative downregulation of proteins in asthmatic BALF (and relative upregulation in control BALF), while red shades indicate relative upregulation of proteins in asthmatic BALF (and relative downregulation of proteins in control BALF). Blue indicates predicted decreases in neutrophil functions, while orange shades indicate predicted increases. More intense (darker) colors indicate greater increases or decreases. Together, this network indicated net downregulation of neutrophil activation, chemotaxis, and phagocytosis, and upregulation of neutrophil migration, adhesion, infiltration, and respiratory burst. Broken lines indicate a relationship between the proteins and the neutrophil functions.