Figure 2.

Spearman correlations between abdominal pain–associated species and metabolites in 45 pediatric subjects. Relationships between whole-genome sequencing–based species abundances and metabolites (middle), metabolites and abdominal pain (bottom), and species and abdominal pain (right) are depicted. Each metabolite depicted herein correlates with abdominal pain frequency (PF) and/or mean abdominal pain (MP). All of the included species are significantly correlated with abdominal pain and/or abdominal pain–associated metabolites. False-discovery rate–corrected statistical significance is denoted as follows: *q < 0.05, **q < 0.01, and ^#q < 0.10. n = 23 pediatric subjects with IBS; n = 22 HCs. DiHome, (12Z)-9,10-dihydroxyoctadec-12-enoic acid.