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. 2019 May;21(3):449–461. doi: 10.1016/j.jmoldx.2019.01.006

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© 2019 American Society for Investigative Pathology and the Association for Molecular Pathology. Published by Elsevier Inc. All rights reserved.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

A multi-omics network of bacterial species (green triangles), metagenomic pathways (yellow diamonds), and metabolite abundances (blue spheres) separates pediatric IBS cases (red squares) from HCs (cyan squares). Features (ie, species, pathways, and metabolites) were included if they had F values >7 in the comparison of IBS cases versus HCs. The edge-weighted, spring-embedded layout was used to visualize network structure. n = 23 pediatric IBS cases; n = 22 HCs. TCA, tricarboxylic acid.