Table 1.
Time point | Control | Asphyxia (+) | Asphyxia (−) | Asphyxia + SOD | Asphyxia + C3 | Asphyxia + Oxypurinol (5 mg/kg) | Asphyxia + Oxypurinol (50 mg/kg) |
---|---|---|---|---|---|---|---|
MEAN ARTERIAL BLOOD PRESSURE (mm Hg) | |||||||
Baseline | 56 ± 1 | 57 ± 2 | 59 ± 1 | 55 ± 1 | 54 ± 1 | 55 ± 2 | 56 ± 1 |
1 h | 55 ± 1 | 54 ± 2 | 58 ± 1 | 53 ± 1 | 51 ± 1 | 54 ± 2 | 55 ± 1 |
2 h | 56 ± 1 | 52 ± 2 | 55 ± 1# | 53 ± 0 | 52 ± 2 | 51 ± 1 | 54 ± 1 |
BLOOD GLUCOSE (mg/dL) | |||||||
Baseline | 88 ± 7 | 104 ± 6 | 103 ± 5 | 95 ± 5 | 126 ± 3* | 111 ± 22 | 91 ± 4 |
1 h | 92 ± 7 | 120 ± 5* | 117 ± 10 | 106 ± 8 | 135 ± 8* | 112 ± 12 | 109 ± 10 |
2 h | 93 ± 7 | 122 ± 6 | 107 ± 10 | 93 ± 10 | 124 ± 15 | 88 ± 10 | 89 ± 8 |
ARTERIAL pH | |||||||
Baseline | 7.38 ± 0.01 | 7.36 ± 0.01 | 7.38 ± 0.01 | 7.34 ± 0.02 | 7.34 ± 0.02 | 7.41 ± 0.02 | 7.37 ± 0.02 |
1 h | 7.36 ± 0.01 | 7.31 ± 0.02 | 7.32 ± 0.02 | 7.29 ± 0.02 | 7.29 ± 0.01 | 7.35 ± 0.02 | 7.33 ± 0.02 |
2 h | 7.35 ± 0.01 | 7.35 ± 0.02 | 7.34 ± 0.02 | 7.33 ± 0.02 | 7.34 ± 0.02 | 7.40 ± 0.01 | 7.36 ± 0.01 |
ARTERIAL PARTIAL PRESSURE OF CO2 (mm Hg) | |||||||
Baseline | 40 ± 1 | 38 ± 1 | 38 ± 1 | 38 ± 1 | 43 ± 1 | 37 ± 1 | 37 ± 2 |
1 h | 41 ± 1 | 38 ± 2 | 40 ± 1 | 39 ± 1 | 41 ± 3 | 37 ± 2 | 40 ± 2 |
2 h | 40 ± 1 | 35 ± 1 | 39 ± 1 | 39 ± 2 | 41 ± 2 | 36 ± 2 | 38 ± 3 |
ARTERIAL PARTIAL PRESSURE OF O2 (mm Hg) | |||||||
Baseline | 94 ± 3 | 98 ± 3 | 95 ± 2 | 94 ± 3 | 88 ± 2 | 96 ± 3 | 91 ± 2 |
1 h | 96 ± 2 | 101 ± 3 | 105 ± 4 | 103 ± 4 | 98 ± 4 | 93 ± 3 | 102 ± 4 |
2 h | 92 ± 2 | 105 ± 4 | 100 ± 2 | 94 ± 2 | 112 ± 11* | 94 ± 3 | 99 ± 4 |
(+), with aCSF superfusion across the cranial window; (−), without aCSF superfusion across the cranial window.
p < 0.05 vs. control at the same time point;
p < 0.05 vs. baseline mean arterial blood pressure value for asphyxia without aCSF superfusion.