Table 4.
Estimated CFH haplotypes in the 25 cases and the 48 “supercontrols.”
| Estimated CFH haplotype | Haplotype reference number | Haplotype frequency | P-value | |
|---|---|---|---|---|
| Cases | Supercontrols | |||
| CGTAAG | H4a | 0.492 | 0.638 | ns |
| TGTAAG | H4b | 0.338 | 0.279 | ns |
| CATAAG | H2 | 0.07 | 0.019 | ns |
| TGCAGG | H5 | 0.042 | 0 | ns |
| TGTGGT | H3 | 0.024 | 0.01 | 0.04 |
The estimated allele frequencies of each CFH haplotype in cases (aHUS patients with anti-FHs and FHR1 deficiency) and “supercontrols” (adult healthy subjects with homozygous CFHR1 deletion) were shown. The minimal informative SNPs within CFH gene considered for this analysis were rs3753394, rs800292, rs1061170, rs3753396, rs1410996, and rs1065489.