Table 4.

PFS and OS single factor and multi-factor cox regression

Variables	Univariate cox analysis results			Multi-factor cox analysis results
HR	95% CI of HR	P-value	HR	95% CI of HR	P-value
PFS
Age	0.984	0.966–1.003	0.102
Gender (female)	1.54	0.896–2.645	0.118	1.887	1.029–3.462	0.04*
Alcohol intake (non)	1.214	0.851–1.731	0.285
MELD score	1.154	0.970–1.371	0.105	1.292	1.054–1.582	0.014*
Maximal lesion diameter (≥3cm)	1.283	0.786–2.095	0.319	2.592	1.223–5.493	0.013*
TB	0.994	0.979–1.010	0.459
Albumin	1.006	0.996–1.016	0.249
Creatinine	0.996	0.979–1.012	0.616
INR	1.454	1.056–2.001	0.022*
Noninvade	0.378	0.197–0.727	0.004*
Blood-supply (poor)	1.141	0.935–1.392	0.193	1.258	0.994–1.593	0.057
Portal invasion	1.539	0.749–3.161	0.24
AFP (≥20)	1.077	0.725–1.600	0.714
Child-Pugh grade (B)	1.879	0.862–4.099	0.113
PA-TACE	0.293	0.202–0.425	<0.001*	0.293	0.179–0.481	<0.001*
OS
Age	0.988	0.954–1.023	0.494
Gender (female)	1.896	0.790–4.553	0.152
Alcohol intake (non)	1.095	0.573–2.093	0.783
MELD score	1.459	0.968–2.198	0.071
Maximal lesion diameter (≥3cm)	1.39	0.539–2.587	0.496
TB	1.005	0.982–1.028	0.682
Albumin	0.999	0.982–1.016	0.87
Creatinine	0.996	0.967–1.025	0.77
INR	0.906	0.497–1.652	0.747
Noninvade	0.716	0.219–2.335	0.579
Blood-supply (poor)	1.37	0.905–2.075	0.137	1.861	1.006–3.443	0.048*
Portal invasion	1.737	0.533–5.660	0.36
AFP (≥20)	1.321	0.640–2.728	0.452	2.363	0.913–6.113	0.076
Child-Pugh grade (B)	1.94	0.579–6.506	0.283
PA-TACE	0.164	0.074–0.360	<0.001*	0.159	0.047–0.537	0.003*

Note: *Significant difference (P<0.05).

Abbreviations: AFP, α-fetoprotein; INR, international normalized ratio; OS, overall survival; PA-TACE, postoperative adjuvant TACE; PFS, progress-free survival; TB, total bilirubin; MELD, Model of End-Stage Liver Disease.