Table S2.
Summary of the immunophenotypic profile of acute leukemia with aberrant phenotypes, Brazil, 2005–2017
| Total Np/Nt (%) |
T/M-MPAL Np/Nt (%) |
ETP-ALL Np/Nt (%) |
AML-M0 Np/Nt (%) |
p-value* | |
|---|---|---|---|---|---|
| CD34 | 35/43 (81.4) | 6/9 (66.7) | 22/26 (84.6) | 7/8 (87.5) | 0.435 |
| HLA-DR | 23/40 (57.5) | 8/9 (88.9) | 8/23 (34.8) | 7/8 (87.5) | <0.01 |
| CD117 | 26/38 (68.4) | 5/9 (55.6) | 15/21 (71.4) | 6/8 (75) | 0.626 |
| TdT | 24/34 (70.6) | 6/7 (85.7) | 15/21 (71.4) | 3/6 (50) | 0.367 |
| CD10 | 7/41 (17.1) | 1/7 (14.3) | 5/26 (19.2) | 1/8 (12.5) | 0.886 |
| aMPO | 9/44 (20.5) | 8/10 (80) | 0/26 (0) | 1/8 (12.5) | <0.001 |
| CD11b | 19/38 (50) | 7/10 (70) | 11/22 (50) | 1/6 (16.7) | 0.118 |
| CD13/CD33 | 39/42 (92.9) | 10/10 (100) | 21/24 (87.5) | 8/8 (100) | 0.298 |
| CD14 | 1/30 (3.3) | 1/9 (11.1) | 0/13 (0) | 0/8 (0) | 0.299 |
| CD15 | 4/32 (12.5) | 1/7 (14.3) | 1/17 (5.9) | 2/8 (25) | 0.398 |
| CD56 | 6/33 (18.2) | 2/9 (22.2) | 2/17 (11.8) | 2/7 (28.6) | 0.678 |
| T-cell markers | |||||
| cyCD3 | 36/44 (81.8) | 10/10 (100) | 26/26 (100) | 0/8 (0) | <0.001 |
| CD7 | 43/44 (97.7) | 10/10 (100) | 23/24 (95.8) | 8/8 (100) | 0.702 |
| CD1a | 1/38 (2.6) | 1/10 (10) | 0/26 (0) | 0/2 (0) | 0.263 |
| CD2 | 17/38 (44.7) | 9/10 (90) | 8/26 (29.2) | 0/2 (0) | <0.01 |
| CD5 | 21/38 (55.3) | 5/10 (50) | 16/26 (61.5) | 0/2 (0) | 0.223 |
| mCD3 | 4/44 (9.1) | 3/10 (30) | 1/26 (3.8) | 0/8 (0) | 0.031 |
| CD4 | 5/41 (12.2) | 3/10 (30) | 1/26 (3.8) | 1/5 (20) | 0.085 |
| CD8 | 7/41 (17.1) | 4/10 (40) | 3/26 (11.5) | 0/5 (0) | 0.070 |
Notes: Number of cases positive/number of total cases tested. Cases were considered positive when expressed ≥20% in blast cells. *p-value calculated by Exact Fisher test comparing T/M- MPAL, ETP-ALL, and AML-M0.
Abbreviations: T/M-MPAL, T-lymphoid/myeloid mixed phenotype acute leukemia; ETP-ALL, early T-cell precursor acute lymphoblastic leukemia; AML-M0, minimally differentiated acute myeloid leukemia; Np, number of positive cases; Nt, number of total tested; cy, cytoplasmatic; m, membrane.