Table 1.

Recombinant proteins produced in the last decade using H. polymorpha as host.

Protein	Maximum production	Promoter	Utilized carbon source	References
Human serum albumin (HSA)	5.8 g/L	MOX	Glycerol/Methanol	Youn et al., 2010
Heat shock protein gp96	≈150 mg/L	FMD	Methanol	Li et al., 2011
Ferritin (FTH1)	1.9 g/L	FMD	Glycerol/Methanol	Eilert et al., 2012
Bacteriocin enterocin A (EntA)	4.8 μg/mL	TEF1 (Arxula adeninivorans)	Glucose	Borrero et al., 2012
Granulocyte colony stimulating factor (GCSF)	ND	FMD	Methanol	Talebkhan et al., 2016
Streptavidin (SAV)	≈751 mg/L	FMD	Methanol	Wetzel et al., 2016
Human parathyroid hormone (PTH) fragment 1–34	150 mg/L	FMD	Glycerol/Methanol	Mueller et al., 2013
Penicillin	1.1 μg/mL	MOX	Glucose/Methanol	Gidijala et al., 2009
Human papilomavirus 16 L1 Protein (HPV16L1)	78.6 mg/L	MOX	Methanol	Li et al., 2009
HPV type 16 L1-L2 chimeric protein (SAF)	132.10 mg/L	MOX	Methanol	Bredell et al., 2018
Rabies virus glycoprotein (RVG)	14.6 mg/L	FMD	Glycerol	Qian et al., 2013
Hepatitis B virus PreS2-S antigen	250 mg/L	MOX	Methanol	Xu et al., 2014
Human papillomavirus Type 52 L1 Protein (HPV 52 L1)	ND	MOX	Methanol	Liu et al., 2015
Rotavirus VP6 protein (RV VP6)	3350.71 mg/L	MOX	Methanol	Bredell et al., 2016
Hepatitis E virus-like particles (HEV VLPs)	1.0 g/L	MOX	Methanol	Su et al., 2017
Uricase from Candida utilis	52.3 U/mL	MOX	Methanol	Chen et al., 2008
Lipase from Yarrowia lipolytica (YlLip11)	1,144 U/L	TEF1 (Arxula adeninivorans)	Glucose	Kumari et al., 2015
T4 lysozyme	0.49 g/L	Not used	Glycerol	Wang et al., 2011
Staphylokinase (SAK)	1,212 mg/L	FMD	Glycerol/Methanol	Moussa et al., 2012

ND, Not Determined.