FIGURE 3.

The percentage survival of mice following challenge with F. tularensis SchuS4 by the intranasal route. Mice were challenged with 100 CFU of F. tularensis by the intranasal route and treated with finafloxacin (37.5 mg/kg) by the oral route every 8 h or ciprofloxacin (30 mg/kg) by the intraperitoneal route every 12 h. Regimens were initiated at 24 h post-challenge, and continued for 1 (A), 3 (B), or 7 (C) days. Control animals received PBS by the IP route or diluent by the oral route. A group of animals were infected and received no treatment. Statistical analysis was performed using a Mantel-Haenszel log rank test. ^∗∗p < 0.01.