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. 2019 May 1;10:904. doi: 10.3389/fmicb.2019.00904

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Copyright © 2019 Dstl. Authors: Barnes, Hamblin, Richards, Laws, Vente, Atkins and Harding.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The percentage weight change following ciprofloxacin and finafloxacin therapy in mice challenged with F. tularensis SchuS4 by the intranasal route. Mice were challenged with 101 CFU of F. tularensis by the intranasal route and treated with finafloxacin (37.5 mg/kg) by the oral route every 8 h or ciprofloxacin (30 mg/kg) by the intraperitoneal route every 12 h. Control animals received PBS by the IP route or diluent by the oral route. A group of animals were infected and received no treatment. The graphs show the percentage change in weight over time when antibiotics were initiated at 24 (A), 48 (B), 72 (C), or 96 h (D) post-challenge and continued for 7 days. Each line represents an individual mouse.