Table 1.
Chimeric PvMSP1 and Pvs25 peptide pools.
| Peptide pool | Sequence | Peptide pool | Sequence |
|---|---|---|---|
| cPvMSP1 Pool 1 | MANFVGKFLELQIPG VGKFLELQIPGHTDL LELQIPGHTDLLHLG IPGHTDLLHLGPGPG TDLLHLGPGPGFNQL HLGPGPGFNQLMHVI GPGFNQLMHVINFHY NQLMHVINFHYDLLR HVINFHYDLLRANVH FHYDLLRANVHGPGP LLRANVHGPGPGLDM NVHGPGPGLDMLKKV PGPGLDMLKKVVLGL LDMLKKVVLGLWKPL KKVVLGLWKPLDNIK LGLWKPLDNIKDGPG KPLDNIKDGPGPGLE NIKDGPGPGLEYYLR GPGPGLEYYLREKAK GLEYYLREKAKMAGT YLREKAKMAGTLIIP KAKMAGTLIIPESGP AGTLIIPESGPGPGS IIPESGPGPGSKDQI SGPGPGSKDQIKKLT PGSKDQIKKLTSLKN DQIKKLTSLKNKLER KLTSLKNKLERRQNG LKNKLERRQNGPGPG LERRQNGPGPGVKSS |
Pvs25 Pool 1 | MAVDAVTVDTICKNG AVTVDTICKNGQLVQ DTICKNGQLVQMSNH KNGQLVQMSNHFKCM LVQMSNHFKCMCNEG SNHFKCMCNEGLVHL KCMCNEGLVHLSENT NEGLVHLSENTCEEK VHLSENTCEEKNECK ENTCEEKNECKKETL EEKNECKKETLGKAC ECKKETLGKACGEFG ETLGKACGEFGQCIE KACGEFGQCIENPDP EFGQCIENPDPAQVN CIENPDPAQVNMYKC PDPAQVNMYKCGCIQ QVNMYKCGCIQGYTL YKCGCIQGYTLKEDT CIQGYTLKEDTCVLD |
| cPvMSP1 Pool 2 | QNGPGPGVKSSGLLE GPGVKSSGLLEKLMK KSSGLLEKLMKSKLI LLEKLMKSKLIKENE LMKSKLIKENESKEI KLIKENESKEILSQL ENESKEILSQLLNVQ KEILSQLLNVQTQLL SQLLNVQTQLLTMSS NVQTQLLTMSSEHTC QLLTMSSEHTCIDTN MSSEHTCIDTNVPDN HTCIDTNVPDNAACY DTNVPDNAACYRYLD PDNAACYRYLDGTEE ACYRYLDGTEEWRCL YLDGTEEWRCLLTFK TEEWRCLLTFKEEGG RCLLTFKEEGGKCVP TFKEEGGKCVPASNV EGGKCVPASNVTCKD CVPASNVTCKDNNGG SNVTCKDNNGGCAPE CKDNNGGCAPEAECK NGGCAPEAECKMTDS APEAECKMTDSNEIV ECKMTDSNEIVCKCT TDSNEIVCKCTKEGS EIVCKCTKEGSEPLF KCTKEGSEPLFEGVF EGSEPLFEGVFCSSS |
Pvs25 Pool 2 | YTLKEDTCVLDVCQY EDTCVLDVCQYKNCG VLDVCQYKNCGESGE CQYKNCGESGECIVE NCGESGECIVEYLSE SGECIVEYLSETQSA IVEYLSETQSAGCSC LSETQSAGCSCAIGK QSAGCSCAIGKVPNP CSCAIGKVPNPEDEK IGKVPNPEDEKKCTK PNPEDEKKCTKTGET DEKKCTKTGETACQL CTKTGETACQLKCNT GETACQLKCNTDNEV CQLKCNTDNEVCKNV CNTDNEVCKNVEGVY NEVCKNVEGVYKCQC KNVEGVYKCQCMEGF GVYKCQCMEGFTFDK CQCMEGFTFDKEKNV EGFTFDKEKNVCLLE |
Peptide pools used for stimulation of T cells for assessment of cytokine production after the second immunization. cPvMSP1 Pool 1 represents MSP1 T cell epitopes present in cPvMSP1. Pool 2 represents the extended MSP119 kD protein fragment. Pvs25 pools 1 and 2 cover the full sequence of the Pvs25 protein.