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. 2019 May 1;10:474. doi: 10.3389/fphys.2019.00474

Table 1.

Differentially expressed genes after inactivity and subsequent exercise for muscle- and mitochondria-related proteins in vastus lateralis. GSE24215 dataset.

Category Term Count % p Benjamini Fold enrichment
Gene enrichment analysis of downregulated genes after inactivity
UP_KEYWORDS Mitochondrion 49 20.94 1.5E-16 3.14E-14 4.00
UP_KEYWORDS Muscle protein 8 3.42 5E-06 0.00036 11.74
KEGG_PATHWAY hsa00190:Oxidative phosphorylation 8 3.42 0.00303 0.03573 4.12
KEGG_PATHWAY hsa04920:Adipocytokine signaling pathway 7 2.99 0.00049 0.01087 6.84
GOTERM_CC_DIRECT GO:0005753∼mitochondrial proton-transporting ATPsynthase complex 4 1.71 0.00200 0.05541 15.62
Gene enrichment analysis of upregulated genes after inactivity
UP_KEYWORDS Muscle protein 6 1.78 0.00296 0.08000 6.10
Gene enrichment analysis of downregulated genes after exercise
COG_ONTOLOGY Energy production and conversion 4 3.15 0.00086 0.00257 18.33
Gene enrichment analysis of upregulated genes after exercise
UP_KEYWORDS Mitochondrion 41 11.39 7.3E-06 0.00031 2.15

Category, original database/resource where the term orient; term, enriched terms associated with the gene list; count, genes involved in term; %, percentage of genes involved/total genes; p, modified fisher exact p-value, EASE Score; Benjamini, statistical correction; fold enrichment, down (up) regulated genes in a specific category/term over total down (up) regulated genes (%)/number of genes in that category/term over total number of genes (%). Lists of the top DEG in Supplementary Tables S1, S2. For DEG analysis, see Supplementary Table legends.