Table 1. Demographics and clinical characteristics of the study population (1988–2006).
| Derivation Cohort | Validation Cohort | |||
|---|---|---|---|---|
| N | N = 49,856 | N = 9,842 | P-value | |
| Recipient data | ||||
| Recipient's diagnosis | 59,698 | 0.937 | ||
| Non-ischemic cardiomyopathy | 21,789 (44%) | 4,258 (43%) | ||
| Ischemic cardiomyopathy | 21,911 (44%) | 4,355 (44%) | ||
| Graft failure | 971 (2%) | 203 (2%) | ||
| Valvular heart disease | 1,530 (3%) | 296 (3%) | ||
| Congenital | 950 (2%) | 191 (2%) | ||
| Miscellaneous | 2,705 (5%) | 539 (5%) | ||
| Age (year) | 59,698 | 51 ± 11 | 51 ± 11 | 0.212 |
| Female gender | 59,698 | 10,052 (20%) | 1,978 (20%) | 0.884 |
| Height (cm) | 48,042 | 173 ± 9 | 173 ± 9 | 0.605 |
| Weight (kg) | 48,042 | 76 ± 15 | 76 ± 15 | 0.412 |
| COPD | 23,035 | 615 (3%) | 136 (4%) | 0.217 |
| Hypertension | 23,784 | 7,262 (38%) | 1,447 (37%) | 0.600 |
| Peripheral vascular disease | 23,783 | 648 (3%) | 170 (4%) | <0.001 |
| Unstable angina | 29,089 | 2,373 (10%) | 523 (11%) | 0.010 |
| History of cerebrovascular disease | 23,791 | 714 (4%) | 153 (4%) | 0.360 |
| Infection within two weeks | 25,516 | 2,077 (10%) | 442 (11%) | 0.124 |
| Cytomegalovirus status | 31,998 | 18,823 (70%) | 3,693 (70%) | 0.504 |
| Amiodarone prior to transplant | 23,794 | 4,727 (24%) | 888 (23%) | 0.122 |
| Antiarrhymics | 22,134 | 6,916 (37%) | 1,364 (37%) | 0.947 |
| Previous transplant | 47,311 | 1,263 (3%) | 261 (3%) | 0.412 |
| Previous cardiac surgery | 5,600 | 2,056 (44%) | 391 (43%) | 0.893 |
| PVR (wood units) | 21,689 | 2.1 (1.4–3.2) | 2.1 (1.4–3.2) | 0.718 |
| Creatinine (μmol/l) | 27,909 | 106 (88–132) | 106 (88–132) | 0.834 |
| Serum bilirubin (mg/dl) | 25,181 | 0.9 (0.6–1.4) | 0.9 (0.6–1.4) | 0.482 |
| Dialysis pre-transplanted | 2,033 | 28 (2%) | 3 (1%) | 0.334 |
| Medical condition at transplant | 59,698 | 0.549 | ||
| Not hospitalized | 31,507 (63%) | 6,252 (64%) | ||
| Hospitalized | 4,903 (10%) | 933 (10%) | ||
| ICU | 13,446 (27%) | 2,657 (27%) | ||
| Life support | ||||
| Inotropic support prior to transplant | 39,128 | 12,901 (39%) | 2,548 (40%) | 0.754 |
| Mechanical ventilation | 36,421 | 938 (3%) | 195 (3%) | 0.435 |
| Intra-aortic balloon pump | 37,399 | 2,123 (7%) | 387 (6%) | 0.182 |
| ECMO | 36,542 | 92 (0%) | 14 (0%) | 0.377 |
| Donor data | ||||
| Age (year) | 59,698 | 32 ± 13 | 32 ± 13 | 0.278 |
| Female gender | 59,698 | 15,470 (31%) | 3,096 (31%) | 0.402 |
| History of hypertension | 28,421 | 2,636 (11%) | 517 (11%) | 0.981 |
| Cytomegalovirus status | 43,209 | 20,425 (57%) | 4,015 (57%) | 0.774 |
| Ischemia time (minutes) | 47,359 | 178 ± 63 | 178 ± 63 | 0.416 |
| Era of transplantation | 59,698 | 0.824 | ||
| 2001–2006 | 13,933 (28%) | 2,724 (28%) | ||
| 1996–2000 | 14,088 (28%) | 2,786 (28%) | ||
| 1991–1995 | 15,017 (30%) | 3,005 (31%) | ||
| 1988–1990 | 6,818 (14%) | 1,327 (13%) |
Data are mean ± SD, number (%). The numbers are calculated on patients with available data. COPD, chronic obstructive pulmonary disease; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; PVR, pulmonary vascular resistance. Test used: χ2-test; Wilcoxon test.