Table 2. Cell-cycle alterations were evaluated using PI-FACS analysis and a representative result is presented in ECRF24 and A2780 cells Apoptosis rates were measured by PI-FACS analysis (n = 4) after 72 h incubation with two concentrations of drugs 1–3.
| Compound (μM) | ECRF24 | A2780 | ||||
|---|---|---|---|---|---|---|
| G1/G0 | G2/M | Apoptosis | G1/G0 | G2/M | Apoptosis | |
| 1 (0.17) | 54.6 | 27.3 | 6.16 | 68.0 | 13.5 | 0.2 |
| 1 (0.43) | 7.9 | 2.5 | 44.8 | 50.8 | 28.9 | 8.8 |
| 2 (0.06) | 15.1 | 4.5 | 45 | 16.0 | 11.2 | 47.1 |
| 2 (0.17) | 20.7 | 7.4 | 34.7 | 22.4 | 19.2 | 26.5 |
| 3 (20) | 56.2 | 30.8 | 3.2 | 63.3 | 9.2 | 0.5 |
| 3 (60) | 61.6 | 25.6 | 3.2 | 61.7 | 32.7 | 0.3 |