Table 1.

Scoring system used to prioritize chemotypes.

PARAMETER	SCORE
	6	3	1	0
IC50 WT PfPKG (μM)	≤0.1	0.1< × <0.5	≥0.5
IC50 HuPKGIα/WT PfPKG		>1000	10< × <1000	<10
HepG2 (μM)		100	50≤ × <100	<50
LEa		≥0.3	<0.3
LLEb		>5	<5
IFIc		<5	5≤ × <10	≥10
Compounds/cluster		≥5	2< × <4	1

^aLigand efficiency

^bLipophilic ligand efficiency

^cInhibition Frequency Index