Table 2.
Cardiopulmonary bypass (CPB) patient’s demographics, and pre-surgery clinical data and blood chemistries analyzed with respect to the expression of leukocytes TLR4 signaling intermediates on postoperative Day 1.
| TLR4-SI positive | TLR4-SI negative | p value | |
|---|---|---|---|
| Patients# | 31 | 13 | |
| Sex (M) | 18 | 8 | |
| Age (y) | 67.5 (63.1, 71.8) | 71.9 (66.4, 77.5) | 0.2 |
| BMI (kg/m2) | 30.4 (28.2, 32.6) | 28.3 (25.4, 31.2) | 0.3 |
| BSA (m2) | 2.0 (1.9, 2.1) | 1.8 (1.7, 1.9) | <0.03 |
| HbA1C (%) | 5.8 (5.6, 5.9) | 5.7 (5.5, 6.1) | 0.4 |
| Fasting glucose (mg/dL) | 118 (111, 126) | 111 (99, 123) | 0.3 |
| Fasting Insulin (µU/mL)* | 4.0 (2.7, 4.3) | 5.7 (4.0, 7.3) | 0.1 |
| ALT (IU/L)* | 20 (13, 29) | 22 (15, 34) | 0.4 |
| AST (IU/L)* | 20 (16, 29) | 23 (1, 37) | 0.1 |
| Bilirubin (µmol/L)* | 0.4 (0.3, 0.5) | 0.7 (0.5, 1.0) | <0.01 |
| Cholesterol (mg/dL)* | 164 (146, 204) | 156 (136, 179) | 0.4 |
| Creatinine (mg/dL) | 0.9 (0.8, 1.0) | 0.9 (0.7, 1.3) | 0.1 |
| HDL (mg/dL)* | 50 (41, 63) | 45 (34, 54.) | 0.2 |
| Triglyceride (mg/dL)* | 107 (78, 143) | 112 (80, 135) | 1.0 |
| LDL (mg/dL) | 105 (90, 119) | 83 (67, 100) | 0.1 |
| IL-6 (pg/ml)* | 3 (1, 9) | 2 (1, 5) | 0.7 |
| CRP (ng/ml)* | 2.9 (0.9, 3.7) | 2.2 (0.5, 8.4) | 0.8 |
Data are presented as mean and 95% confidence interval (95%CI) of mean, or as median and percentiles ((Q25, Q75%; marked by (*)). Data were compared using t-test or Mann-Whitney U test. A p-value < 0.05 was considered statistically significant.