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. 2019 Mar 6;218(5):1686–1705. doi: 10.1083/jcb.201810023

Figure 5.

Figure 5.

Synaptic transmission and motor performance are impaired in Macf1 muscle-conditional mutant mice. (A) Motor performance of male and female Macf1 muscle-conditional mutant mice was impaired at P180, as assessed by grip strength and rotarod assays. The body weight of Macf1 mutant mice was normal. The mean ± SEM values from more than five mice are shown (*, P < 0.05; **, P < 0.005; ***, P < 0.0005). (B) The frequency of mEPPs was reduced and the mEPP amplitude was increased in P180 Macf1 muscle-conditional mice. The mean ± SEM values from four mice are shown. (C) Quantal content was reduced by 20% in Macf1 muscle-conditional mutant mice. The mean ± SEM values from four mice are shown (**, P < 0.005). The rise time and half width of the EPP were normal in Macf1 mutant mice. Likewise, the muscle resting membrane potential was similar in Hsa::Cre; Macf1f/− (70.3 ± 1.3 mV, n = 4 mice, n = 37 myofibers) and Macf1f/+ control mice (71.2 ± 0.8 mV, n = 4 mice, n = 38 myofibers).