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. Author manuscript; available in PMC: 2019 May 8.
Published in final edited form as: J Thromb Thrombolysis. 2016 Feb;41(2):343–350. doi: 10.1007/s11239-015-1290-7

Table 1.

Candidate SNPs, rationale, and genotype frequencies in CaPs and 1000 Genomes Project.

Marker Gene/SNP function Prior rationale Minor
allele		 HWE (P)
CaPs		 MAF
CaPs		 MAF
1000G CEU
rs10761741 JMJD1C/intron Epinephrined, PLT T 0.29 0.38 0.48
rs11144351 PIP5K1B/intron ADPc, Epinephrinea G 0.30 0.14 0.13
rs12359150 CUBN/intron ADPa, Epinephrinea A 0.53 0.10 0.07
rs12566888 PEAR1 /intron ADPd, Epinephrined T 0.006 0.08 0.05
rs16876805e ATP6VOD2/Ile336Val ADPa, Epinephrinea C 1 0.009 0.008
rs2363910 SHH/intergenic ADPd T 0.27 0.10 0.08
rs2479008 GMDS/intergenic ADPa, Epinephrinea T 0.57 0.14 0.17
rs342286 PIK3CG /intergenic PLT, Epinephrined G 0.31 0.45 0.45
rs4128880 RGS18/intergenic ADPb, Epinephrinea T 0.70 0.48 0.42
rs467053 ADAMTS2/intron ADPa, Epinephrinea C 0.95 0.41 0.38
rs7940646 MRVI1/intron ADPb, Epinephrineb T 0.90 0.30 0.23
rs9996294 RAPGEF2/intergenic ADPb G 0.30 0.12 0.09
a

P<5×10−5

b

P<5×10−6

c

P<5.0×10−7

d

P<5.0×10−8 for platelet reactivity in Johnson et al. 2009.

e

Marker excluded from association analyses

Abbreviations: SNP, single nucleotide polymorphism; MAF, minor allele frequency; CaPs, Caerphilly Prospective Study in Men; HWE, Hardy-Weinberg Equilibrium; 1000G CEU, 1000 Genomes CEU population; PLT, platelet count; MPV, mean platelet volume