Table 2:
Association of SNPs with platelet reactivity measures (p<0.01).
| No Exclusions | Exclusionsb | ||||||
|---|---|---|---|---|---|---|---|
| Marker | Gene | Allele | Phenotype | Effect | p-value | Effect | p-value |
| rs12566888 | PEAR1 | T | 1° Aggregation ADP | −2.29 | 9.98×10−5 | −1.83 | 4.71×10−3 |
| 2° Aggregation ADP | −0.13 | 1.51×10−7 | −0.11 | 2.56×10−5 | |||
| Thrombin | −2.07 | 1.91×10−6 | −2.17 | 8.07×10−6 | |||
| ADP 1.5 Ω Impedance | 0.76 | 2.36×10−3 | 0.81 | 3.86×10−3 | |||
| rs10761741 | JMJD1C | G | ADP 1.5 Ω Impedance | 0.44 | 1.35×10−3 | 0.46 | 2.76×10−3 |
| ADP 21.5 Ω Impedance | 0.42 | 8.52×10−3 | 0.42 | 1.77×10−2 | |||
| rs2363910 | SHH | T | 2° Aggregation ADP | −0.06 | 6.65×10−3 | −0.04 | 1.11×10−1 |
| rs4128880 | RGS18 | C | 2° Aggregation ADP | −0.04 | 4.35×10−3 | −0.04 | 8.08×10−3 |
| rs7940646a | MRVI1 | C | Absolute Shear Stress | 11.01 | 5.04×10−3 | 10.21 | 1.55×10−2 |
a
Under dominant model
b
Exclusions included taking anti-platelet medications and fasting for < 8 hours before blood draw