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. Author manuscript; available in PMC: 2019 Dec 12.
Published in final edited form as: Chem Rev. 2018 Oct 31;118(23):11298–11323. doi: 10.1021/acs.chemrev.8b00513

Figure 13.

Figure 13.

Methods for discerning whether damage site transfer involves continuous contact of hOGG1 with the DNA backbone. (a, b) Molecular models of a DNA duplex containing two 8-oxoG sites 10 bp apart, (a) on the same DNA strand (blue) or (b) on opposite strands (red).87 (c) Molecular model of DNA duplex containing a site-specific fluorescein iodoacetamide covalent label (green) at a phosphorothioate linkage located between two 8-oxoG sites on the same DNA strand (blue). Adapted with permission from ref 47. Copyright 2014 Oxford University Press.