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. Author manuscript; available in PMC: 2019 Dec 12.
Published in final edited form as: Chem Rev. 2018 Oct 31;118(23):11298–11323. doi: 10.1021/acs.chemrev.8b00513

Figure 19.

Figure 19.

Salt dependence of the apparent rate of target-site location by Egr-1 changes the relative contributions of the 1D, 3D, and IS pathways for target-site location, (a, left panel) The IS rate (kIS) increases in a log–linear fashion with salt, which was attributed to salt-enhanced release of Egr-1 from competitor DNA. (b, right panel) The diffusion constant for 1D translocation increases in a biphasic fashion with respect to salt concentration.3 The salt-resistant region was attributed to associative DNA translocation, and the salt-enhanced region was attributed to salt-enhanced dissociative transfers. Adapted with permission from ref 3. Copyright 2014 Oxford University Press.