Table 3.

Multivariate Logistic Regression model With Independent Predictors of Day 4 Persistence and Mortality

Variable	Persistencec OR (95% CI)	p-value	Mortalityd OR (95% CI)	p-value
72h IL-10/TNF ratioa	2.98 (1.39 − 6.39)	0.005	9.87 (2.64 − 36.91)	<0.001
Source risk categoryb
High vs. Low Risk	0.83 (0.27 − 2.59)	0.64	0.62 (0.12 − 3.12)	0.91
Intermediate vs. Low	1.08 (0.41 − 2.87)	0.67	0.32 (0.07 − 1.56)	0.17
Age	1.01 (0.98 − 1.03)	0.68	1.02 (0.98 − 1.07)	0.29
Female	1.22 (0.56 − 2.64)	0.62	3.09 (0.86 − 11.15)	0.09
Immunosuppressed	0.31 (0.06 − 1.54)	0.15	0.76 (0.12 − 4.88)	0.77
ICU admission	2.87 (1.33 − 6.18)	<0.01	9.48 (2.39 − 37.62)	<0.01

Abbreviations: CI, confidence interval; IL, interleukin; TNF, tumor necrosis factor; OR, odds

ratio

^aIL 10/TNF ratio cutoff value used in model was 1.00 for persistence and 2.56 for mortality;

^bBased on mortality risk (low <10%: intravenous catheter, urinary tract, ear-nose- larynx, gynecologic sources, and manipulation-related sources, 10–20%: osteoarticular, soft-tissue, and unknown sources, >20%: endovascular, lower respiratory tract, and abdominal sources, and CNS foci) (5);

^cr² = 0.19;

^dr² = 0.42