TABLE 1.
Model parameters
| MET Channel | whole cell Ca2+ current | 14 pA base, 4.0 pA apex | (Johnson et al., 2011) |
| Fixed buffer1 | Concentration | 1 mM (stereocilia) | (Xu et al., 1997) |
| dissociation coefficient | 10 µM | ||
| forward binding rate | 107 M−1s−1 | ||
| Oncomodulin CalbindinD28k | Concentration2 (mM) | 4 mM (apex) 6 mM (base) | (Hackney et al., 2005) |
| dissociation coefficient | 0.5 µM | (Lee et al., 2000) | |
| forward binding rate3 | 2×107 M−1s−1 | (Nagerl et al., 2000) | |
| diffusion coefficient | 50 µm2/s | (Schmidt et al., 2003) | |
| PMCA | max. velocity of transport4 | 2.0 µmol/m2s | (Beurg et al., 2010) |
| dissociation coefficient | 0.5 µM | (Carafoli et al., 1994) | |
| Mitochondria Uniporter MCU | transport rate5 | 114 mM/s | (Wingrove et al., 1984) |
| dissociation coefficient | 40 µM | (Xu et al., 1997) | |
| Mitochondria NCX | transport rate | 1.8 mM/s | (Patterson et al., 2007) |
| dissociation coefficient | 5 µM | (Hilgemann et al., 1991) |
1
Fixed buffer values are assumed based on ranges in different neuronal Ca2+ models. Ca2+ binding ratio, (total buffer concentration)/KCa =100:1 (Tucker & Fettiplace 1995)
2
This is the density of the Ca-binding sites, not the density of the molecules
3
This parameter value was unavailable for oncomodulin so value for calbindinD28k used instead.
4
2.0 μmol/m2s = (2000 pumps/μm2)×(600 ions/pumps/2) /(6.0×1023ions/mol)
5
This value is derived from Wingrove et al..(1984) Flux, J = 4 nmol/mg/min at C = 0.5 μM.