Table 2:
Pearson’s correlations, 95% intervals, and p values between microstructural measures (histomorphometric and μCT-based) and UTE-MRI parameters (bi-component T2* fitting and MT modeling). Significance for all correlations were assessed using non-parametric bootstrap (with resampling by specimen) to adjust for within-specimen dependence.
| Bi-component T2* fitting | MT-modelling | ||||||
|---|---|---|---|---|---|---|---|
| Frac1 | T2*1 | T2*2 | MMF | T2MM | |||
| μCT | Porosity |
−0.71 [−0.89,−0.18] p<0.01 |
−0.76 [−0.89,−0.51] p<0.01 |
0.09 [−0.31,0.42] p=0.74 |
−0.87 [−0.92,−0.77] p<0.01 |
0.37 [−0.24,0.61] P=0.18 |
|
| BMD |
0.68 [0.17,0.83] p<0.01 |
0.61 [0.45,0.75] p<0.01 |
−0.06 [−0.29,0.31] p=0.86 |
0.85 [0.70,0.91] p<0.01 |
−0.25 [−0.68,0.43] P=0.50 |
||
| Histomorphometry | Porosity | All pores |
−0.71 [−0.85,−0.45] p<0.01 |
−0.71 [−0.83,−0.53] p<0.01 |
0.11 [−0.31,0.44] p=0.63 |
−0.81 [−0.89,−0.65] p<0.01 |
0.61 [0.25,0.78] p<0.01 |
|
Small pores (<40 μm) |
−0.52 [−0.74,−0.23] P<0.01 |
−0.42 [−0.81,−0.09] p=0.02 |
0.02 [−0.26,0.39] p=0.88 |
−0.56 [−0.77,−0.34] p<0.01 |
0.26 [−0.22,0.76] p=0.26 |
||
|
Large pores (>40 μm) |
−0.69 [−0.83,−0.43] p<0.01 |
−0.70 [−0.82,−0.53] p<0.01 |
0.11 [−0.31,0.45] p=0.62 |
−0.78 [−0.88,−0.64] p<0.01 |
0.61 [0.29,0.78] p<0.01 |
||
| Pore size | All pores |
−0.55 [−0.74,−0.22] P<0.01 |
−0.71 [−0.85,−0.53] p<0.01 |
0.15 [−0.39,0.54] p=0.58 |
−0.73 [−0.85,−0.55] p<0.01 |
0.65 [0.41,0.81] p<0.01 |
|
|
Small pores (<40 μm) |
−0.60 [−0.80,−0.35] p<0.01 |
−0.42 [−0.78,0.16] p=0.17 |
−0.19 [−0.61,0.20] p=0.37 |
−0.51 [−0.79,−0.21] p<0.01 |
0.27 [−0.16,0.67] p=0.23 |
||
|
Large pores (>40 μm) |
−0.55 [−0.76,−0.21] p<0.01 |
−0.70 [−0.86,0.52] p<0.01 |
0.14 [−0.40,0.52] p=0.61 |
−0.74 [−0.86,−0.54] p<0.01 |
0.64 [0.39,0.80] p<0.01 |
||