Table 3.
Association between clinical factor and the frequency of abnormal karyotype
| Abnormal karyotype | Non-viable trisomy | Viable trisomy | ||||
|---|---|---|---|---|---|---|
| OR (95% CI) | aORa (95% CI) | OR (95% CI) | aORa (95% CI) | OR (95% CI) | aORa (95% CI) | |
| Maternal age (years) | ||||||
| < 35 | Reference | Reference | Reference | Reference | Reference | Reference |
| 35 to < 40 | 2.56 (1.38–4.76) | 2.73 (1.45–5.15) | 2.05 (1.19–3.53) | 2.82 (1.54–5.17) | 2.64 (1.11–6.29) | 3.18 (1.19–8.45) |
| ≥ 40 | 4.57 (2.12–9.84) | 5.15 (2.35–11.3) | 2.78 (1.56–4.95) | 4.59 (2.36–8.92) | 2.95 (1.21–7.21) | 3.02 (1.11–8.24) |
| Previous miscarriages (n) | ||||||
| < 2 | Reference | Reference | Reference | Reference | Reference | Reference |
| ≥ 2 | 0.53 (0.31–0.92) | 0.48 (0.27–0.85) | 1.06 (0.71–1.61) | 0.89 (0.56–1.41) | 0.43 (0.24–0.77) | 0.53 (0.27–1.03) |
| Embryonic/fetal size at miscarriage (mm) | ||||||
| Empty | Reference | Reference | Reference | Reference | Reference | Reference |
| < 10 | 1.37 (0.64–2.96) | 1.46 (0.66–3.26) | 2.23 (1.21–4.09) | 2.41 (1.27–4.58) | 1.20 (0.21–6.74) | 1.26 (0.22–7.12) |
| 10 to < 20 | 1.78 (0.77–4.11) | 1.56 (0.65–3.74) | 0.73 (0.40–1.34) | 0.60 (0.31–1.14) | 8.66 (1.96–38.3) | 8.49 (1.90–37.9) |
| ≥ 20 | 0.56 (0.25–1.22) | 0.41 (0.18–0.95) | 0.01 (0.00–0.09) | 0.01 (0.00–0.07) | 38.8 (8.80–171) | 36.8 (8.26–164) |
OR, odds ratio; aOR, adjusted odds ratio; CI, confidence interval
aaOR was measured using a multivariate model including the maternal age, the number of previous miscarriage, and embryonic/fetal size at miscarriage