Table 3.
Characteristics of previous studies and the present study
| References (author, year) | Country (ethnicity) | Male infertility | Genotyping assay | Case, control (n) | HWE | ||
|---|---|---|---|---|---|---|---|
| Total | Allele | Genotype | |||||
| PRMT6 rs12097821 polymorphism | G/T | GG/GT/TT | |||||
| Sato et al. 2013[6] | Japan (Asian) | NOAa | PCR-RFLP | 490, 1167 | 795/185, 1917/417 | 322/151/17, 788/341/38 | 0.881 |
| Hu et al., 2012[12] | China (Asian) | NOA | SNP Array Chip | 2920, 5727 | 4106/1734, 8562/2892 | 1456/1194/270, 3205/2152/370 | 0.731 |
| Zou et al., 2014[10] | China (Asian) | NOA | Sequencing | 525, 512 | 735/315, 731/293 | 265/205/55, 255/221/36 | 0.200 |
| Tu et al., 2015[7] | China (Asian) | NOA | TaqMan assay | 545, 632 | 786/304, 905/359 | 280/226/39, 317/271/44 | 0.172 |
| Liu-1 et al., 2017[8] | China (Asian) | Male infertility | Snapshot PCR | 184, 51 | 266/102, 78/24 | 99/68/17, 29/20/2 | 0.522 |
| NOA | Snapshot PCR | 97, 51 | 136/58, 78/24 | 48/40/9, 29/20/2 | 0.522 | ||
| Oligozoospermia | Snapshot PCR | 87, 51 | 130/44, 78/24 | 51/28/8, 29/20/2 | 0.522 | ||
| Liu-2 et al., 2017[9] | China (Asian) | Male infertility | MassARRAY | 134, 454 | 182/86, 657/251 | 61/60/13, 232/193/29 | 0.182 |
| Asthenozoospermia | MassARRAY | 95, 454 | 130/60, 657/251 | 45/40/10, 232/193/29 | 0.182 | ||
| Oligoasthenozoospermia | MassARRAY | 21, 454 | 25/17, 657/251 | 6/13/2, 232/193/29 | 0.182 | ||
| Oligozoospermia | MassARRAY | 18, 454 | 27/9, 657/251 | 10/7/1, 232/193/29 | 0.182 | ||
| This study, 2018 | China (Asian) | Male infertility | RFLP-PCR | 631, 720 | 925/337, 1110/330 | 340/246/45, 428/254/38 | 0.968 |
| NOA | RFLP-PCR | 301, 720 | 425/177, 1110/330 | 150/125/26, 428/254/38 | 0.968 | ||
| Oligozoospermia | RFLP-PCR | 330, 720 | 500/160, 1110/330 | 190/121/19, 428/254/38 | 0.968 | ||
| PEX10 rs2477686 polymorphism | G/C | GG/GC/CC | |||||
| Sato et al., 2013[6] | Japan (Asian) | NOA | PCR-RFLP | 485, 1161 | 131/839, 313/2009 | 9/113/363, 18/277/866 | 0.436 |
| Hu et al., 2012[12] | China (Asian) | NOA | SNP Array Chip | 2882, 5729 | 837/4927, 1225/10233 | 88/661/2133, 76/1073/4580 | 0.146 |
| Zou et al., 2014[10] | China (Asian) | NOA | Sequencing | 524, 518 | 138/910,117/919 | 13/112/399,11/95/412 | 0.054 |
| Tu et al., 2015[7] | China (Asian) | NOA | TaqMan assay | 545, 632 | 154/936, 160/1104 | 14/126/405, 11/138/483 | 0.753 |
| Liu-1 et al., 2017[8] | China (Asian) | Male infertility | Snapshot PCR | 183, 51 | 36/330, 17/85 | 1/34/148, 0/17/34 | 0.153 |
| NOA | Snapshot PCR | 96, 51 | 22/170, 17/85 | 1/20/75, 0/17/34 | 0.153 | ||
| Oligozoospermia | Snapshot PCR | 87, 51 | 14/160, 17/85 | 0/14/73, 0/17/34 | 0.153 | ||
| Liu-2 et al., 2017[9] | China (Asian) | Male infertility | MassARRAY | 135, 456 | 38/232, 114/798 | 7/24/104, 5/104/347 | 0.363 |
| Asthenozoospermia | MassARRAY | 95, 456 | 22/168, 114/798 | 3/16/76, 5/104/347 | 0.363 | ||
| Oligoasthenozoospermia | MassARRAY | 22, 456 | 13/31, 114/798 | 4/5/13, 5/104/347 | 0.363 | ||
| Oligozoospermia | MassARRAY | 18, 456 | 3/33, 114/798 | 0/3/15, 5/104/347 | 0.363 | ||
| This study, 2018 | China (Asian) | Male infertility | PCR-RFLP | 631, 720 | 146/1316, 171/1269 | 9/128/494, 10/151/559 | 0.957 |
| NOA | PCR-RFLP | 301, 720 | 85/517, 171/1269 | 6/73/222, 10/151/559 | 0.957 | ||
| Oligozoospermia | PCR-RFLP | 330, 720 | 61/599, 171/1269 | 3/55/272, 10/151/559 | 0.957 | ||
| SIRPA-SIRPG rs6080550 polymorphism | A/G | AA/AG/GG | |||||
| Sato et al., 2013[6] | Japan (Asian) | NOA | RFLP-PCR | 481, 1158 | 134/828, 333/1983 | 8/118/355, 30/273/855 | 0.148 |
| Hu et al.,2012[12] | China (Asian) | NOA | SNP Array Chip | 2923, 5731 | 1340/4506, 2177/9285 | 154/1032/1737, 215/1747/3769 | 0.478 |
| Liu-2 et al., 2017[9] | China (Asian) | Male infertility | MassARRAY | 135, 454 | 113/157, 402/506 | 27/59/49, 84/234/136 | 0.343 |
| Asthenozoospermia | MassARRAY | 95, 454 | 85/105, 402/506 | 21/43/31, 84/234/136 | 0.343 | ||
| Oligoasthenozoospermia | MassARRAY | 22, 454 | 17/27, 402/506 | 2/13/7, 84/234/136 | 0.343 | ||
| Oligozoospermia | MassARRAY | 18, 454 | 11/25, 402/506 | 4/3/11, 84/234/136 | 0.343 | ||
| This study, 2018 | China (Asian) | Male infertility | RFLP-PCR | 631, 720 | 368/894, 363/1077 | 53/261/317, 46/271/403 | 0.961 |
| NOA | RFLP-PCR | 301, 720 | 172/430, 363/1077 | 24/123/154, 46/271/403 | 0.961 | ||
| Oligozoospermia | RFLP-PCR | 330, 720 | 196/464, 363/1077 | 29/138/163, 46/271/403 | 0.961 | ||
| SOX5 rs10842262 polymorphism | G/C | GG/GC/CC | |||||
| Sato et al. 2013[6] | Japan (Asian) | NOA | PCR-RFLP | 487, 1155 | 373/601, 827/1483 | 81/211/195, 146/535/474 | 0.794 |
| Hu et al., 2012[12] | China (Asian) | NOA | SNP Array Chip | 2887, 5711 | 2121/3653, 3656/7766 | 338/1445/1104, 581/2494/2636 | 0.802 |
| Zou et al., 2014[10] | China (Asian) | NOA | sequencing | 522, 529 | 351/693, 291/767 | 65/221/236, 41/209/279 | 0.831 |
| Tu et al., 2015[7] | China (Asian) | NOA | TaqMan assay | 545, 632 | 385/705, 401/863 | 58/269/218, 65/271/296 | 0.798 |
| Liu-1 et al., 2017[8] | China (Asian) | Male infertility | Snapshot PCR | 177, 51 | 89/265, 28/74 | 15/59/103, 6/16/29 | 0.129 |
| NOA | Snapshot PCR | 96, 51 | 55/137, 28/74 | 9/37/50, 6/16/29 | 0.129 | ||
| Oligozoospermia | Snapshot PCR | 81, 51 | 34/128, 28/74 | 6/22/53, 6/16/29 | 0.129 | ||
| This study, 2018 | China (Asian) | Male infertility | PCR-RFLP | 631, 720 | 437/826, 436/1004 | 76/285/270, 66/304/350 | 0.998 |
| NOA | PCR-RFLP | 301, 720 | 222/380, 436/1004 | 41/140/120, 66/304/350 | 0.998 | ||
| Oligozoospermia | PCR-RFLP | 330, 720 | 215/446, 436/1004 | 35/145/150, 66/304/350 | 0.998 | ||
aNOA, nonobstructive azoospermia