Table 5.
Genetic model | Heterogeneity test | Summary OR (95% CI) | Hypothesis test | Studies (n) | |||
---|---|---|---|---|---|---|---|
Q | P | I 2 | Z | P | |||
rs2477686 and male infertility | |||||||
G vs. C | 30.65 | < 0.001 | 80.4% | 1.058 (0.86–1.30) | 0.55 | 0.585 | 7 |
GG vs. CC | 9.88 | 0.130 | 39.3% | 1.973 (1.55–2.51) | 5.51 | < 0.001 | 7 |
CG vs.CC | 19.14 | 0.004 | 68.6% | 1.026 (0.85–1.24) | 0.27 | 0.788 | 7 |
GG vs. CG | 7.77 | 0.256 | 22.7% | 1.662 (1.29–2.13) | 3.99 | < 0.001 | 7 |
GG + CG vs.CC | 21.49 | 0.002 | 72.1% | 1.06 (0.88–1.29) | 0.64 | 0.524 | 7 |
GG vs. GC + CC | 9.29 | 0.158 | 35.4% | 1.904 (1.50–2.42) | 5.24 | < 0.001 | 7 |
rs2477686 and nonobstructive azoospermia (NOA) | |||||||
G vs. C | 14.55 | 0.012 | 65.6% | 1.167 (0.99–1.37) | 1.86 | 0.063 | 6 |
GG vs. CC | 5.66 | 0.341 | 11.6% | 1.982 (1.55–2.54) | 5.38 | < 0.001 | 6 |
CG vs.CC | 10.38 | 0.065 | 51.8% | 1.138 (0.97–1.33) | 1.61 | 0.106 | 6 |
GG vs.CG | 2.93 | 0.710 | 0% | 1.612 (1.25–2.09) | 3.64 | < 0.001 | 6 |
GG + CG vs.CC | 12.83 | 0.025 | 61.0% | 1.169 (1.08–1.27) | 1.72 | 0.085 | 6 |
GG vs. GC + CC | 5.00 | 0.416 | 0% | 1.898 (1.48–2.43) | 5.06 | < 0.001 | 6 |
rs2477686 and oligozoospermia | |||||||
G vs. C | 1.75 | 0.417 | 0% | 0.698 (0.53–0.92) | 2.53 | 0.011 | 3 |
GG vs. CC | 0.54 | 0.463 | 0% | 0.712 (0.22–2.35) | 0.56 | 0.577 | 2 |
CG vs.CC | 2.20 | 0.333 | 9.0% | 0.680 (0.50–0.92) | 2.47 | 0.014 | 3 |
GG vs.CG | 0.49 | 0.483 | 0% | 0.943 (0.28–3.20) | 0.09 | 0.925 | 2 |
GG + CG vs.CC | 2.12 | 0.346 | 5.7% | 0.690 (0.59–0.81) | 2.59 | 0.010 | 3 |
GG vs. GC + CC | 0.57 | 0.450 | 0% | 0.752 (0.23–2.48) | 0.47 | 0.640 | 2 |