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. 2019 Mar 13;36(4):759–768. doi: 10.1007/s10815-019-01417-w

Table 5.

Meta-analysis of associations between PEX10 rs2477686 polymorphism and male infertility susceptibility

Genetic model Heterogeneity test Summary OR (95% CI) Hypothesis test Studies (n)
Q P I 2 Z P
rs2477686 and male infertility
 G vs. C 30.65 < 0.001 80.4% 1.058 (0.86–1.30) 0.55 0.585 7
 GG vs. CC 9.88 0.130 39.3% 1.973 (1.55–2.51) 5.51 < 0.001 7
 CG vs.CC 19.14 0.004 68.6% 1.026 (0.85–1.24) 0.27 0.788 7
 GG vs. CG 7.77 0.256 22.7% 1.662 (1.29–2.13) 3.99 < 0.001 7
 GG + CG vs.CC 21.49 0.002 72.1% 1.06 (0.88–1.29) 0.64 0.524 7
 GG vs. GC + CC 9.29 0.158 35.4% 1.904 (1.50–2.42) 5.24 < 0.001 7
rs2477686 and nonobstructive azoospermia (NOA)
 G vs. C 14.55 0.012 65.6% 1.167 (0.99–1.37) 1.86 0.063 6
 GG vs. CC 5.66 0.341 11.6% 1.982 (1.55–2.54) 5.38 < 0.001 6
 CG vs.CC 10.38 0.065 51.8% 1.138 (0.97–1.33) 1.61 0.106 6
 GG vs.CG 2.93 0.710 0% 1.612 (1.25–2.09) 3.64 < 0.001 6
 GG + CG vs.CC 12.83 0.025 61.0% 1.169 (1.08–1.27) 1.72 0.085 6
 GG vs. GC + CC 5.00 0.416 0% 1.898 (1.48–2.43) 5.06 < 0.001 6
rs2477686 and oligozoospermia
 G vs. C 1.75 0.417 0% 0.698 (0.53–0.92) 2.53 0.011 3
 GG vs. CC 0.54 0.463 0% 0.712 (0.22–2.35) 0.56 0.577 2
 CG vs.CC 2.20 0.333 9.0% 0.680 (0.50–0.92) 2.47 0.014 3
 GG vs.CG 0.49 0.483 0% 0.943 (0.28–3.20) 0.09 0.925 2
 GG + CG vs.CC 2.12 0.346 5.7% 0.690 (0.59–0.81) 2.59 0.010 3
 GG vs. GC + CC 0.57 0.450 0% 0.752 (0.23–2.48) 0.47 0.640 2