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. 2019 May 7;21:115. doi: 10.1186/s13075-019-1893-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flowchart of patient selection. Figure depicting patient selection for the current study. EAC, early arthritis clinic; RA, rheumatoid arthritis; DAS, disease activity score; DMARD, disease-modifying antirheumatic drug; MTX, methotrexate. Patients in the regular treatment group that did not fulfill the inclusion criteria of the IMPROVED study were excluded for reasons of comparability. *For patients who participated in the IMPROVED study, follow-up after conclusion of the study (after 5 years) continued in the EAC cohort according to routine care