Table 3.
Comparison of Mean or Median Levels in the 2 Locations
| Study | SB Crohn’s | LB Crohn’s | Reference standard/scoring system used | Key result | Inference |
|---|---|---|---|---|---|
| af Björkesten [14] | 33 | 50 | SES-CD | Median FC level in SB: 86 µg/g | No difference between both locations |
| LB: 158 µg/g (NS) | |||||
| Gecse [17] | 9 | 20 | SES-CD | Mean FC level in SB: 297±81 µg/g | Higher in LB location |
| LB: 1,523±97 µg/g (P<0.0001) | |||||
| Jensen [19] | 13 | 16 | Endoscopy/capsule/surgery | Median FC level in SB: 890 mg/kg | No difference between both locations |
| LB: 830 mg/kg (NS) | |||||
| Lobatón [67] | 26 | 45 | CDEIS | Median FC level in SB: 420.5 µg/g | Higher in LB location |
| LB: 1,297 µg/g (P=0.013) | |||||
| Makanyanga [68] | 18 | 15 | MEGS | Mean FC level in SB: 319.1 μg/g | No difference between both locations |
| LB: 342 μg/g (NS) | |||||
| Maltz [69] | 9 | 18 | Endoscopy | Median FC level in SB: 442 µg/g | Higher in LB location |
| LB: 66 µg/g (P<0.002) | |||||
| Schoepfer [70] | 35 | 20 | SES-CD | Mean FC level in SB: 287±279 μg/g | No difference between both locations |
| LB: 401±312 μg/g (NS) | |||||
| Sipponen [18] | 19 | 14 | CDEIS | Median FC level in SB: 180 µg/g | Higher in LB location |
| LB: 1,383 µg/g (P=0.017) | |||||
| Moniuszko [74] | NA | NA | SES-CD, CT enteroclysis | Median FC level in SB: 195 μg/g | No difference between both locations |
| LB: 401 μg/g (NS) | |||||
| Goutorbe [75] | 13 | 12 | CDEIS | Median FC level in SB: 841 µg/g | No difference between both locations |
| LB: 1,575.5 µg/g (NS) | |||||
| Lin [76] | 4 | 8 | CDEIS | Median FC level in SB: 2,693 μg/g | No difference between both locations |
| LB: 176 μg/g (NS) |
SB, small bowel; LB, large bowel; SES-CD, Simple Endoscopic Score for Crohn’s Disease; FC, fecal calprotectin; CDEIS, Crohn’s Disease Endoscopic Index of Severity; MEGS, MRI enterography global score; NA, not available.