Table 2.

Univariate and Multivariate Analyses in the Derivation Cohort

Variable	Total cohort	ACRN (n=393)	Non-ACRN (n=41,309)	Univariate analysis P-value	Multivariate analysis P-value
Age (yr)		41.1±5.0	38.9±5.3	<0.001	<0.001
Sex				0.016	0.164
Female	11,933	91 (0.8)	11,842 (99.2)
Male	29,769	302 (1.0)	29,467 (99.0)
Alcohol
No	12,878	141 (1.1)	12,737 (98.9)
Non-heavy drinker	27,548	240 (0.9)	27,308 (99.1)	0.030	0.005
Heavy drinkera	1,276	12 (0.9)	1,264 (99.1)	0.611	0.209
Smoking
Never	23,091	204 (0.9)	22,887 (99.1)
Former smoker	6,646	49 (0.7)	6,597 (99.3)	0.254	0.330
Current smoker	11,965	140 (1.2)	11,825 (98.8)	0.010	0.009
Family history of colorectal cancer				0.537	0.991
No	40,242	377 (0.9)	39,865 (99.1)
Yes	1,460	16 (1.1)	1,444 (98.9)
Exercise				0.592	0.798
No	18,436	179 (1.0)	18,257 (99.0)
Yesb	23,266	214 (0.9)	23,052 (99.1)
Obesity				<0.001	0.114
No	27,757	227 (0.8)	27,530 (99.2)
Yesc	13,945	166 (1.2)	13,779 (98.8)
Diabetes				<0.001	0.678
No	32,605	269 (0.8)	32,336 (99.2)
Yes	9,097	124 (1.4)	8,973 (98.6)
Insulin (FB)		5.6±3.4	5.1±3.3	0.003	0.750
HbA1c ≥6.5%				<0.001	0.015
No	40,681	367 (0.9)	40,314 (99.1)
Yes	1,021	26 (2.5)	995 (97.5)
Glucose ≥100 (mg/dL)				<0.001	0.262
No	33,472	277 (0.8)	33,195 (99.2)
Yes	8,230	116 (1.4)	8,114 (98.6)
Total cholesterol (mg/dL)		204.4±35.4	198.4±34.2	<0.001	0.413
HDL-cholesterol (mg/dL)		53.3±12.9	55.1±13.7	0.008	0.501
LDL-cholesterol (mg/dL)		129.4±31.8	124.0±31.7	<0.001	0.242
Triglyceride (mg/dL)		130.6±85.9	115.0±76.1	<0.001	0.255
SBP (mmHg)		113.0±13.4	113.0±12.9	0.890	0.698
DBP (mmHg)		72.2±9.7	72.3±9.6	0.325	0.469

Values are presented as mean±SD or number (%).

^aMore than 4 times per week as heavy.

^bMore than once per week.

^cBMI ≥25 kg/m².

ACRN, advanced colorectal neoplasm; FB, fasting blood; HbA1c, hemoglobin A1c; SBP, systolic blood pressure; DBP, diastolic blood pressure.