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. 2019 May 8;20:158. doi: 10.1186/s12882-019-1364-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Renal dysfunction is prevented by pirfenidone. a) Initial body weight, b) final

body weight (c) mean arterial blood pressure, (d) renal blood flow, (e) BUN and (f) creatinine clearance. The sham group is represented by white bars or dots, the I/R group by black bars or dots and the IR + PFN group by gray bars or dots. Six rats per group were studied. Data are shown as the means ± SD. * = p < 0.05 vs. sham and I/R + PFN groups. The significance of the differences between groups was assessed by ANOVA using the Bonferroni correction for multiple comparisons