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. 2019 May 8;20:158. doi: 10.1186/s12882-019-1364-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Mechanisms involved in renoprotection conferred by pirfenidone. a) Catalase mRNA levels, b) GPX mRNA levels, c) eNOS mRNA levels, d) urinary NO2/NO3 excretion The sham group is represented by white bars; the I/R group, by gray bars; and the IR + PFN group, by black bars. Six rats per group were studied. The results are presents as mean of two different measurements. Data are shown as the means ± SD. + = p < 0.05 vs. I/R, & = p < 0.05 vs. sham group. The significance of the differences between groups was assessed by ANOVA using the Bonferroni correction for multiple comparisons