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. 2019 May 7;16:61. doi: 10.1186/s12985-019-1152-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flow chart of the study population and design. EVR: EVR was defined as HBV DNA decrease to < 100,000 copies/ml at week 12; ADV: adefovir; EVR: early virological response; PEG-IFN alfa-2a: Peginterferon alfa-2a