Table 6.
MBL2 additional 5′ variant’s distribution and comparison of genotypes and alleles in RVVI types with controls
| No. (%) of controls | No. (%) of VVI types | Genotype comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| BV vs HC | VVC vs HC | MI vs HC | ||||||||
| HC (N = 203) | BV (n = 97) | VVC (n = 62) | MI (n = 41) | OR (95% CI) | p-value | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| rs11003124 | ||||||||||
| Genotypes | ||||||||||
| TT | 125 (61.51) | 64 (65.91) | 36 (58.12) | 23 (56.12) | 1 | 1 | 1 | |||
| TG | 64 (31.52) | 27 (27.82) | 26 (41.91) | 15 (36.51) | 0.82 (0.47–1.41) | 0.48 | 1.41(0.78–2.53) | 0.25 | 1.27 (0.62–2.60) | 0.50 |
| GG | 14 (6.81) | 6 (6.11) | 0 (0.00) | 3 (7.31) | 0.83 (0.30–2.28) | 0.72 | – | NA | 1.16 (0.30–4.37) | 0.82 |
| Alleles | ||||||||||
| T | 314 (77.31) | 155 (79.81) | 98 (79.12) | 61 (74.31) | 1 | 1 | 1 | |||
| G | 92 (22.62) | 39 (20.12) | 26 (20.91) | 21 (25.62) | 0.85 (0.56–1.30) | 0.47 | 0.90 (0.55–1.47) | 0.69 | 1.17 (0.67–2.03) | 0.56 |
| rs7084554 | ||||||||||
| Genotypes | ||||||||||
| TT | 143 (70.40) | 59 (60.82) | 35 (56.41) | 21 (51.21) | 1 | 1 | 1 | |||
| TC | 49 (24.10) | 28 (28.81) | 27 (43.52) | 17 (41.42) | 1.38 (0.79–2.41) | 0.24 | 2.25 (1.23 4.09) | 0.007** | 2.36 (1.15–4.83) | 0.01** |
| CC | 11 (5.41) | 10 (10.30) | 0 (0.00) | 3 (7.30) | 2.20 (0.88–5.46) | 0.08 | – | NA | 1.85 (0.47–7.20) | 0.37 |
| Alleles | ||||||||||
| T | 335 (82.50) | 146 (75.21) | 97 (78.21) | 59 (71.90) | 1 | 1 | 1 | |||
| C | 71 (17.40) | 48 (24.72) | 27 (21.72) | 23 (28.01) | 1.55 (1.02–2.34) | 0.03* | 1.31 (0.79–2.15) | 0.28 | 1.83 (1.06–3.17) | 0.02* |
| rs36014597 | ||||||||||
| Genotypes | ||||||||||
| AA | 147 (72.40) | 41 (42.21) | 29 (46.77) | 18 (36.51) | 1 | 1 | 1 | |||
| AG | 44 (21.61) | 50 (51.51) | 33 (53.21) | 19 (46.32) | 4.07 (2.39–6.94) | 3.7 × 10−7*** | 3.80(2.08–6.94) | 1.7 × 10−5*** | 3.52 (1.70–7.29) | 0.0007*** |
| GG | 12 (5.91) | 6 (6.12) | 0 (0.00) | 4 (9.70) | 1.79 (0.63–5.06) | 0.27 | – | NA | 2.72 (0.79–9.34) | 0.111 |
| Alleles | ||||||||||
| A | 338 (83.20) | 132 (68.12) | 81 (65.31) | 49 (59.70) | 1 | 1 | 1 | |||
| G | 68 (16.71) | 62 (31.91) | 33 (26.62) | 27 (32.91) | 2.33 (1.56–3.47) | 3.6 × 10−5*** | 2.02(1.25–3.27) | 0.004** | 2.73 (1.60–4.68) | 0.0002*** |
| rs11003123 | ||||||||||
| Genotypes | ||||||||||
| GG | 84 (41.31) | 36 (37.11) | 26 (41.91) | 16 (39.01) | 1 | 1 | 1 | |||
| GA | 104 (51.22) | 53 (54.62) | 36 (582) | 21 (51.21) | 1.18 (0.71–1.98) | 0.50 | 1.11 (0.62–1.99) | 0.70 | 1.06 (0.52–2.15) | 0.87 |
| AA | 15 (7.38) | 8 (8.21) | 0 (0.00) | 4 (9.71) | 1.24 (0.48–3.19) | 0.64 | – | NA | 1.4 (0.41–4.76) | 0.59 |
| Alleles | ||||||||||
| G | 272 (66.91) | 125 (64.4) | 88 (70.91) | 53 (64.62) | 1 | 1 | 1 | |||
| A | 134 (33.12) | 69 (35.5) | 36 (29.12) | 29 (35.31) | 1.12 (0.78–1.60) | 0.53 | 0.83 (0.53–1.28) | 0.40 | 1.11(0.67–1.82) | 0.67 |
OR odds ratio, CI confidence intervals
* Indicates significant p values (p ≤ 0.05)
** Indicates high significant values (p ≤ 0.01)
*** Indicates highly significant values (p ≤ 0.001)