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. 2019 May 5;18:1534735419848047. doi: 10.1177/1534735419848047

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© The Author(s) 2019

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — 4T1 H17 cells are resistant to doxorubicin and P2Et treatment in vivo. 4T1 H17 cells were inoculated into mouse mammary glands, which were then treated with PBS (control), Dx, or P2Et for 21 days. The tumors were measured and compared among groups. (A and C) Tumor volume (mm³) of 4T1 H17 control cells (PBS) versus 4T1 H17 cells treated with Dx or P2Et. (B and D) Tumor weight of 4T1 H17 control cells versus 4T1 H17 cells treated with Dx or P2Et. (E) Frequency of metastatic tumor cells in the lungs of mice bearing 4T1 H17 tumors treated with Dx or P2Et versus PBS. (F) The recovered cells of the lungs were stained using an ALDEFLUOR kit. Percentage of ALDH⁺ cells in the lungs of mice bearing 4T1 H17 tumors treated with Dx or P2Et versus PBS. In all cases, data are presented as the mean ± SEM. The P values were calculated using the Mann-Whitney U test. **P < .01, ***P < .0001.