Table 1.

Excluded studies

Reference	Rationale for exclusion
Zucchelli G, Bernardi F, Montebugnoli L,De SM [37].	Smoker patients included (<  20 cigarettes/day)
Windisch P, Sculean A, Klein F, et al. [38].	Smoker patients included
Sculean A, Windisch P, Chiantella GC, et al. [45].	Smoker patients included
Minabe M, Kodama T, Kogou T, et al. [39].	Smoker patients included (<  10 cigarettes/day)
Meyle J, Gonzales JR, Bödeker RH, et al. [40].	Smoker patients included (<  20 cigarettes/day)
Sanz M, Tonetti MS, Zabalegui I, et al. [41].	Smoker patients included (<  20 cigarettes/day)
Parashis A, Andronikaki-Faldami A, Tsiklakis K [42].	Smokers patients included
Jepsen J, Heinz BB, Jepse Kn, et al. [43].	Smoker patients included (<  20 cigarettes/day)
Hoffmann T, Richter S, Meyle J, et al. [44].	Smoker patients included (<  20 cigarettes/day)
Röllke L, Schacher B, Wohlfeil M, et al. [46].	Patients > 18 years included
Silvestri M, Ricci G, Rasperini G, Sartori S, Cattaneo V. [47].	Patients > 21 years included
Silvestri M, Sartori S, Rasperini G, et al. [48].	Patients > 21 years included
Farina R, Simonelli A, Rizzi A, et al. [49].	Chronic or aggressive periodontitis patients included
Ghezzi C, Ferrantino L, Bernardini L, Lencioni M, Masiero S. [50].	Chronic or aggressive periodontitis patients included
Pontoriero R, Wennström J, Lindhe J. [51]	Outcomes not reported in terms of early wound healing
Jaiswal R, Deo V. [52]	No intervention treatment (EMD) present
Sculean A, Donos N, Miliauskaite A, Arweiler N, Brecx M. [55]	Report long-term data of a previous included study [56]
Sculean A, Schwarz F, Miliauskaite A, et al. [53].	Report long-term data of a previous included study [56]
Sculean A, Donos N, Schwarz F, et al. [54].	Report long-term data of a previous included study [45]