Table 4.
Author, year of publication | Study design | Power calculation | Setting | Funding sources | Masking | Intervention | Follow-up |
---|---|---|---|---|---|---|---|
A.Sculean et al. 1999a [56] | RCT Split-mouth | No | U | Not specified | Double-blind | EMD vs BM | 8 mo |
A.Sculean et al. 1999b [60] | RCT Double-arm | No | U | Not specified | Double-blind | EMD vs BM | 6 mo |
N. Donos et al. 2004 [62] | RCT Multi-arm Three groups | No | U | Yes | Double-blind | EMD vs BM vs EMD + BM | 12 mo |
P. Cortellini et al. 2005 [57] | Non-RCT Case-cohort study Multi-arm Four groups | No | PP | Yes | Not performed | EMD vs BM vs BM + BG vs e-PTFE TrM | 12 mo |
A. Crea et al. 2008 [61] | RCT Double-arm | No | U | No | Double-blind | EMD vs e-PTFE M | 36 mo |
V. Iorio-Siciliano et al. 2011 [58] | RCT Double-arm | Yes | U | No | Double-blind | EMD vs e-PTFE TrM | 12 mo |
V. Iorio-Siciliano et al. 2014 [59] | RCT Double-arm | Yes | U | Not specified | Single-blind | EMD + DBBM vs BM + DBBM | 12 mo |
BG bone graft, BM bioabsorbable membrane, DBBM deproteinized bovine bone mineral, EMD enamel matrix derivative, e-PTFE expanded polytetrafluoroethylene; mo months, M membrane, PP private practice, RCT randomized clinical trial, TrM titanium reinforced membrane, U university