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. 2019 May 7;19:76. doi: 10.1186/s12903-019-0766-9

Table 4.

Characteristics of included studies

Author, year of publication Study design Power calculation Setting Funding sources Masking Intervention Follow-up
A.Sculean et al. 1999a [56] RCT Split-mouth No U Not specified Double-blind EMD vs BM 8 mo
A.Sculean et al. 1999b [60] RCT Double-arm No U Not specified Double-blind EMD vs BM 6 mo
N. Donos et al. 2004 [62] RCT Multi-arm Three groups No U Yes Double-blind EMD vs BM vs EMD + BM 12 mo
P. Cortellini et al. 2005 [57] Non-RCT Case-cohort study Multi-arm Four groups No PP Yes Not performed EMD vs BM vs BM + BG vs e-PTFE TrM 12 mo
A. Crea et al. 2008 [61] RCT Double-arm No U No Double-blind EMD vs e-PTFE M 36 mo
V. Iorio-Siciliano et al. 2011 [58] RCT Double-arm Yes U No Double-blind EMD vs e-PTFE TrM 12 mo
V. Iorio-Siciliano et al. 2014 [59] RCT Double-arm Yes U Not specified Single-blind EMD + DBBM vs BM + DBBM 12 mo

BG bone graft, BM bioabsorbable membrane, DBBM deproteinized bovine bone mineral, EMD enamel matrix derivative, e-PTFE expanded polytetrafluoroethylene; mo months, M membrane, PP private practice, RCT randomized clinical trial, TrM titanium reinforced membrane, U university