Table 4.

Characteristics of included studies

Author, year of publication	Study design	Power calculation	Setting	Funding sources	Masking	Intervention	Follow-up
A.Sculean et al. 1999a [56]	RCT Split-mouth	No	U	Not specified	Double-blind	EMD vs BM	8 mo
A.Sculean et al. 1999b [60]	RCT Double-arm	No	U	Not specified	Double-blind	EMD vs BM	6 mo
N. Donos et al. 2004 [62]	RCT Multi-arm Three groups	No	U	Yes	Double-blind	EMD vs BM vs EMD + BM	12 mo
P. Cortellini et al. 2005 [57]	Non-RCT Case-cohort study Multi-arm Four groups	No	PP	Yes	Not performed	EMD vs BM vs BM + BG vs e-PTFE TrM	12 mo
A. Crea et al. 2008 [61]	RCT Double-arm	No	U	No	Double-blind	EMD vs e-PTFE M	36 mo
V. Iorio-Siciliano et al. 2011 [58]	RCT Double-arm	Yes	U	No	Double-blind	EMD vs e-PTFE TrM	12 mo
V. Iorio-Siciliano et al. 2014 [59]	RCT Double-arm	Yes	U	Not specified	Single-blind	EMD + DBBM vs BM + DBBM	12 mo

BG bone graft, BM bioabsorbable membrane, DBBM deproteinized bovine bone mineral, EMD enamel matrix derivative, e-PTFE expanded polytetrafluoroethylene; mo months, M membrane, PP private practice, RCT randomized clinical trial, TrM titanium reinforced membrane, U university