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Dixon analysis of rolapitant inhibition of CYP2D6. The concentration of rolapitant was plotted vs. the inverse velocity for each line of dextromethorphan (A) or bufuralol (B) at concentrations of 5 (●), 10 (▴), 50 (■), and 100 µM (◆) to yield Ki values of 34 and 20 µM in assays with dextromethorphan and bufuralol, respectively. Each data point represents an average of an experiment completed in quadruplicate.
