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. 2013 Sep 3;3:2576. doi: 10.1038/srep02576

Figure 1. Dynamic epigenetic modifications in CGIs.

Figure 1

(a) Circos plot of the epigenetic modification profiles for CGIs in the whole genome. The tracks, from outermost to innermost, show the ideogram for the mouse karyotype (using genome build mm8), and the four epigenetic modifications in brain, NPCs and ESCs. The tracks are scaled separately to show modification fluctuations. (b) Distribution of the epigenetic entropies representing the variation of epigenetic modifications during neural differentiation, with lower entropy representing greater epigenetic variation. (c) Circos plot of the entropy of the four kinds of epigenetic modifications in the different genomic regions. The tracks, from outermost to innermost, show the genome region, H3K27me3, H3K4me3, H3K4me2 and DNA methylation. (d) Scatter diagram of DNA methylation entropy and the three kinds of histone modification entropy. PCC is the Pearson correlation coefficient between DNA methylation entropy and one kind of histone modification entropy; p is the significance of the PCC.