Figure 4. Expression of developmental genes regulated by DEM-CGIs at different developmental stages.

(a) Relationships among multiple epigenetic modification on DEM-CGIs and expression of the genes related to them in different genome regions in different development stages. PCC is the Pearson correlation coefficient between the corresponding row and column factors as represented by numbers ranging from −1.0 to 1.0 and color mapped from blue (negative correlation) to red (positive correlation). (b) Relationship between epigenetic modifications and gene expression. Scatter plot (left panel) of epigenetic modification and gene expression in different development stages. Best subsets regression analysis (right panel), where gene expression is the dependent variable and epigenetic modifications are independent variables. * indicates the independent variables in the optimal combination for a given variable number.