TABLE 1.
Clinicopathological Characteristics of Patient Population in Relation to the BRAF Mutation Status and Use of BRAFi
| Variable | Group A | Group B | Group C |
|---|---|---|---|
| No. of patients | 23 | 67 | 108 |
| Sex (%) | |||
| Males | 12 (52.2%) | 38 (56.7%) | 84 (77.8%) |
| Females | 11 (47.8%) | 29 (43.1%) | 24 (22.2%) |
| Age at diagnosis of primary melanoma (yr) | |||
| Median | 53 | 47 | 61 |
| Mean ± SD | 53 ± 17 | 47 ± 13.8 | 61 ± 13.4 |
| Range | 20-80 | 16-74 | 13-84 |
| Site of primary melanoma (%) | |||
| Extremity | 12 (52%) | 19 (28%) | 31 (29%) |
| Trunk | 7 (30%) | 22 (33%) | 28 (26%) |
| Head and neck | 1 (4%) | 16 (24%) | 29 (27%) |
| Occult | 3 (13%) | 11 (16%) | 20 (19%) |
| Ulceration (%) | |||
| Present | 4 (17%) | 15 (22%) | 22 (22.4%) |
| Absent | 6 (26%) | 15 (22%) | 34 (31.5%) |
| Unknown | 13 (57%) | 37 (55%) | 51 (47.2%) |
| Clark's level (%) | |||
| II | 1 (4%) | 2 (3%) | 3 (2.8%) |
| III | 2 (8%) | 4 (6%) | 7 (6.5%) |
| IV | 4 (17%) | 15 (22%) | 25 (23.1%) |
| V | 0 | 1 (1%) | 6 (5.6%) |
| Unknown | 16 (70%) | 44 (66%) | 64 (59.3%) |
| Breslow thickness in mm (%) | |||
| 0.01-1.0 | 2 (9%) | 5 (7%) | 7 (6%) |
| 1.01-2.0 | 3 (13%) | 10 (15%) | 20 (19%) |
| 2.01-4.0 | 6 (26%) | 14 (21%) | 18 (17%) |
| >4.0 | 3 (13%) | 4 (5%) | 17 (16%) |
| Unknown | 8 (35%) | 22 (33%) | 38 (35%) |
| Extracranial metastatic disease | |||
| Active extracranial metastatic disease (%) | 15 (65%) | 58 (86%) | 90 (83%) |
| Mean number of organs with active metastasis (range) | 1.2 (0-3) | 1.8 (0-4) | 2 (0-5) |
Percentages may not equal 100% because of rounding.