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Detection of protein lysine crotonylation. (a) Left: the PTM is currently detected using specific antibodies. Right: in this study, we introduce a specific chemical probe based on a reactive phosphine warhead. (b) Scheme depicting the reaction between crotonylated model compounds, 2, and TCEP. (c) RP-HPLC analysis of the reaction between TCEP (1a) and model compound 2a. Inset: ESI-MS analysis of the product peak.
