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. 2019 Apr 15;12(4):dmm038703. doi: 10.1242/dmm.038703

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 3. — Characterization of pancreatic cancer in tree shrew. (A,B) H&E staining of normal (A) and cancerous pancreatic tissue (B) from tree shrew. is, islet; black arrow, normal duct; red arrows, glandular structures; asterisks, fibrous stroma. (C,D) Active cellular proliferation, as shown by Ki67 immunoreactivity (red). (E-L) Immunohistochemical detection of human pancreatic cancer markers CK19 (E,F), Muc5 (G,H), MMP7 (I,J) and Hes1 (K,L) (red). (M,N) Mucin proteins were stained by Alcian Blue. Normal tissue, C,E,G,I,K,M; tumor tissue, D,F,H,J,L,N.