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. 2019 Apr 15;12(4):dmm038703. doi: 10.1242/dmm.038703

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Detection of ADM in early stages of pancreatic cancer development in tree shrew. (A-H) Tissue was harvested 7 days after injection of the lentivirus, and H&E staining was performed in the pTomo-empty (A), KRAS-shTp53 (B), KRAS-shTp53-shCdkn2a (C), KRAS-shTp53-shCdkn2b (D) and KRAS-shTp53-shCdkn2a/b (E-H) groups. H&E staining shows an increase in the number of ducts in tissue infected by lentivirus KRAS-shTp53-shCdkn2a/b; the areas in the blue line boxes are shown enlarged below. (I) Immunohistochemical analysis of CPA1 (red) and CK19 (green) expression in normal tissue and tissue infected by lentivirus KRAS-shTp53-shCdkn2a/b; arrows indicate double-positive cells.