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. 2019 Apr 15;12(4):dmm038703. doi: 10.1242/dmm.038703

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© 2019. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 5. — The Rb1 signaling pathway is involved in tree shrew pancreatic cancer. (A) Phosphorylation of Rb1 (Ser780) was detected by immunohistochemical staining in tree shrew pancreatic cancer tissue and normal tissue. (B) Phosphorylation of Rb1 (Ser780) was detected at the early stage of tree shrew pancreatic cancer; tissues were harvested 7 days after injection of pTomo-empty, KRAS-shTp53, KRAS-shTp53-shCdkn2a, KRAS-shTp53-shCdkn2b and KRAS-shTp53-shCdkn2a/b lentivirus.