Fig. 2.

Prevalence of nasal, nasopharynx and bulla pathology in Eda^Ta mice. Proportions of FVB and Eda^Ta mice with (A) rhinitis, (B) hyaline droplet change in nasal respiratory epithelium, (C) nasopharyngitis and (D) otitis media. The prevalence of rhinitis, nasopharyngitis and otitis media is significantly reduced by treatment with mAbEDAR1 in (n=2 prenatal only, and n=6 pre- and postnatally treated) P21-P22 Eda^Ta mice and in P85 Eda^Ta mice, compared to untreated and Aprily-2-antibody-treated controls. mAbEDAR1 treatment reduced the prevalence of hyaline droplet change at P85. FVB mice had no rhinitis, nasopharyngitis or otitis media, and hyaline droplet change was only evident in a small proportion of FVB mice at P81-P84. The numbers in the body of the graphs represent the number of tissues examined (nasal, nasopharynx and bullae) in each cohort. The histogram bar represents the mean proportion, and error bars the 95% confidence interval for each proportion. Frequency data were analysed with Fisher's exact tests. Two-tailed tests; ns, not significant (P>0.05), *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.