Table 1.

Clinical evidence of CASP1 involvement in MDD

Clinical evidence	Reference
Increased CASP1 and NLRP3 transcription in PBMC (peripheral blood mononuclear cells) from MDD patients. Increased NLRP3 protein levels in PBMC from MDD patients. Increased IL1B and IL18 in serum from MDD patients which positively correlate with BDI (Beck Depression Inventory) score. Antidepressant treatment decreased NLRP3 and CASP1 transcription in PBMC from MDD patients. Antidepressant treatment decreased IL1B and IL18 in serum from MDD patients.	[61]
IL18 is increased in MDD patients.	[62, 63]
IL18 is increased in patients with panic disorder.	[63]
IL18 promoter variants (rs187238 and rs1946518) associate with higher IL18 transcription and increased susceptibility to MDD in patients exposed to stressful events.	[64]
Polymorphisms in the IL33 gene (rs11792633 and rs7044343) moderate the correlation between history of childhood abuse and recurrent depression in women.	[65]
Patients with recurrent depression have higher peripheral IL33	[65]